Published:2013-11-05 Hits:2148

    Yan  ZHANG   PhD., Professor
    Shanghai Center for Systems Biomedicine

    Shanghai Jiao Tong University
    800 Dong Chuan Road, Minhang, Shanghai, 200240, China
    Tel: +86 21 34206778

  Dr. Yan Zhang is Principal Investigator and professor of Glycobiology & Glycomics Lab,and the director of SCSB(China)-AIST(Japan) Joint Medical Glycomics Laboratory at Shanghai Center for Systems Biomedicine. She has been awarded Shanghai Pujiang Research Fellowship in 2007.
Professor Zhang’s research interests include O-glycosylation of proteins and tumors glycobiology or glycoproteomics.
Her lab’s research aims to understand the roles of O-glycan transferase (ppGalNAc-T) and O-glycosylated protein play in physiological and pathological processes, and exploiting this information for development of diagnostic and therapeutic approaches for human disease. Now she is the committee member of the Committee of Glycoconjugates of Chinese Society of Biochemistry and Molecular Biology, the member of the Chinese Protein Society, and the member of Asian Communications of Glycobiology and Glycotechnology (ACGG).

1993 –1996    Doctor of Biotechnology, Tokyo University, Japan
1991 –1993    Master of Biotechnology, Tokyo University, Japan
1982 –1986    Bachelor of Microbiology, Shan Dong University, China
Work Experience :
2006 – present  Professor/PI ,Shanghai Jiao Tong University, China
              Director of SCSB(China)-AIST(Japan) Joint Medical Glycomics Laboratory
2004 –2006    Research associate, National Institute of Animal Health ,Japan                   
2001 –2004    Research associate, Research Center for Medical Glycoscience , AIST, Japan
1996 –2001    Postdoctoral Fellow, National Institute of Advanced Industrial Science and Technology (AIST)                                       
1986 –1989    Research associate, Shanghai Jiao Tong University,China
Representative Publications (corresponding author & first author):
(1)Zou X, Feng B, Dong TT, Yan GQ, Tan BB, Shen H, Huang A, Zhang X, Zhang MH, Yang PY, Zheng MH, Zhang Y*.(2013) Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. Jounal of Proteomics, 94:473-485.
(2)Tan BB, Qiu YP, Zou X, Chen TL, Xie GX, Cheng Y, Dong TT, Zhao LJ, Feng B,Hu XF, Xu XM, Zhao AH, Zhang MH, Cai GX, Zhou ZX, Zheng MH, Zhang Y*, Jia W. (2013) Metabonomics Identifies Serum Metabolite Markers of Colorectal Cancer. Journal of Proteome Research, 12(6): 3000-3009.
(3)Zhang X, Zhang Y*. (2013) Applications of azide-based bioorthogonal click chemistry in glycobiology. Molecules, 18:7145-7159.
(4)Wang S, Xie WX, Zhang X, Zou X, Zhang Y*. (2012) Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides. Chemical Communications (Camb) , 48 (47): 5907-5909.
(5)Li X, Wang J, Li W, Xu YJ, Shao D, XiE YY, Xie WX, Kubota T, Narimatsu H, Zhang Y*. (2012) Characterization of ppGalNAc-T18, a member of the vertebrate-specific Y subfamily of UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyltransferases.Glycobiology, 22(5):602-615.
(6)Cheng Y, Xie GX, Chen TL, Qiu YP, Zou X, Zheng MH, Tan BB, Feng B, Dong TT, He PG, Zhao LJ, Zhao AH, Xu LS, Zhang Y*, Jia W. (2012) Distinct Urinary Metabolic Profile of Human Colorectal Cancer, Journal of Proteome Research . 11(2): 1354-1363.
(7)Wang J, Peng C, Zhang Y*. (2011) Catalytic activity and structure analysis of the intial glycosyltransferase of O-glycosylation. Chinese Bulletin of Life Sciences 23(7): 619-629. (in Chinese)
(8)Peng C, Togayachi A, Kwon YD, Xie C, Wu G, Zou X, Sato T, Ito H, Tachibana K, Kubota T, Noce T, Narimatsu H, Zhang Y*. (2010) Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. Biochem Biophys Res Commun 402(4): 680-686.
(9)Wang S, Zou X, Zhang Y*. (2010) Mass Spectrometry Based Analysis of Protein O-glycosylation. Progress in Chemistry 22(12): 2388-2395. (in Chinese)
(10)Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka TB, Hennet T, Kubota T, Cheng L, Inaba N, Gotoh M, Togayachi A, Guo J, Hisatomi H, Nakajima K, Nishihara S, Nakamura M, Marth JD, Narimatsu H. (2003) Cloning and Characterization of a New Human UDP-N-Acetyl-α-D-galactosamine: Polypeptide N-Acetylgalactosaminyltransferase, Designated pp-GalNAc-T13, that is Specifically Expressed in Neurons and Synthesizes GalNAc α-Serine/Threonine Antigen.  J Biol Chem. 278: 573-84.
(11)Zhang Y, Pak W. J, I. Maruyama N, and Machida M. (2000) Affinity Selection of DNA-Binding Proteins Displayed on Bacteriophage . J. Biochem, 127: 1057-1063.
(12)Zhang Y, Arai H, Sambongi Y, Igarashi Y and Kodama T. (1998) Heterologous Expression of Hydrogenobacter thermophilus Cytochrome c-552 in the Periplasm of Pseudomonas aeruginosa, Journal of Fermentation & Bioengineering, 85: 346-349.

Representative Publications (co-author):
(1)Tan BB, Matsuda A, Zhang Y, Kuno A, Narimatsu H.(2013) Multilectin-assisted fractionation for improved single-dot tissue glycome profiling toward clinical glycoproteomics. Molecular BioSystems, First published online 12 Nov 2013.
(2)Zhu XJ, Gong QM, Yu DM, Zhang DH, Gu LL, Han Y, Chen Jia, Zhang Y, Zhang XX. (2013) Early serum hepatitis B virus large surface protein level: A strongerpredictor of virological response to peginterferon alfa-2a than thatto entecavir in HBeAg-positive patients with chronic hepatitis B. Journal of Clinical Virology, 57(4):318-22 .
(3)Du DN, Zhu XJ, Kuno A , Matsuda A , Tsuruno C , Yu DM , Zhang Y, Ikehara Y, Tanaka Y, Zhang XX, Narimatsu H. (2012) Comparison of LecT-Hepa and FibroScan for assessment of liver fibrosis in hepatitis B virus infected patients with different ALT levels. Clinica Chimica Acta, 413: 1796–1799.
(4)Zhang XW, Yan XJ, Zhou ZR, Yang F, Wu Z, Sun HB, Liang WX, Song AX, Valérie L, Jeanne M, Zhang QY, Yang HY, Huang QH, Zhou QB, Tong JH, Zhang Y, Wu JU, Hu HY, Thé H, Chen SJ, Chen Z. (2010) Arsenic Trioxide Controls the Fate of the PML-RAR Oncoprotein by Directly Binding PML. Science 328(5975): 240-243.
(5)Zhang Q, Mao JH, Liu P, Huang QH, Lu J, Xie Y, Weng L, Zhang Y, Chen Q, Chen SJ, Chen Z. (2009) A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci USA 106: 3378-3383.
(6)Wei H, Shen J, Pang X, Ding D, Zhang Y, Zhang B, Lu H, Wang T, Zhang C, Hua X, Cui L, Zhao L. (2008) Fatal infection in human flora-associated piglets caused by the opportunistic pathogen Klebsiella pneumoniae from an apparently healthy human donor. J Vet Med Sci 70 (7):715-717.
(7)Li M, Wang B, Zhang M, Rantalainen M, Wang S, Zhou H, Zhang Y, Shen J, Pang X, Zhang M, Wei H, Chen Y, Lu H, Zuo J, Su M, Qiu Y, Jia W, Xiao C, Smith LM, Yang S, Holmes E, Tang H, Zhao G, Nicholson JK, Li L, Zhao L. (2008) Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci USA 105(6): 2117-2122.

Research group of Shanghai ICP 11031250 -1 2013 Shanghai Jiao Tong University pollution control

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